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In experiments carried out in rats in which cholestyramine resin was used like a Software to analyze the part of varied intestinal factors, for instance Extra fat, bile salts and microbial flora, in the event of intestinal tumors induced by potent carcinogens, the incidence of this sort of tumors was observed to get higher in cholestyramine resin-treated rats than on top of things rats.
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The increased fecal lack of bile acids due to cholestyramine resin administration contributes to an increased oxidation of cholesterol to bile acids, a minimize in beta lipoprotein or very low density lipoprotein plasma levels and also a lower in serum cholesterol levels.
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The relevance of this laboratory observation from research in rats into the clinical usage of cholestyramine resin just isn't known. During the LRC-CPPT examine referred to earlier mentioned, the whole incidence of lethal and nonfatal neoplasms was equivalent in both of those treatment method teams. When the numerous categories of tumors are examined, different alimentary system cancers had been somewhat extra prevalent while in the cholestyramine team. The compact quantities plus the numerous classes protect against conclusions from being drawn.
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